HelixLinkerLab: a automatic pipline for protein linker design
An automatic pipline to design de novo helical linkers for protein using structure prediction models and inverse folding
The codebase has to be set as private due to institutional regulations.
Hoping in some day I can share it will you all.
the model would automatically truncate the disorder region and link the target protein with MBP, a rigid protein under cryo-EM.
The project comes from the intuition to link the less rigid protein with MBP, a rigid protein under cryo-EM to make the extraction of their structure easier.
And currently work mainly based on manually design and mutations, but without a model covers all the work of linker design.